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Tylenol use during pregnancy appears to be one piece of this larger environmental puzzle.[⁹⁰⁻⁹⁹] THE TIMELINE: TYLENOL INTRODUCTION AND RISING NEURODEVELOPMENTAL DISORDER RATES The temporal correlation between widespread acetaminophen use and neurodevelopmental disorder prevalence is striking: ACETAMINOPHEN INTRODUCTION AND ADOPTION[⁸³⁻⁸⁹] • 1955: Tylenol (acetaminophen) introduced for clinical use in the United States • 1960s-1970s: First use in pregnancy for pain and fever management • 1980s: Widely recommended as first-line agent for pain and fever in pregnancy • Late 1980s-1990s: Increased use for post-vaccination symptom management in infants (replacing aspirin due to Reye’s syndrome concerns) • 2000s-present: Routine use in newborns/infants after vaccination