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however, their application to in vivo exposures is relevant as demonstrated by studies investigating the roles of the transcription factors nuclear factor (erythroid-derived 2)-like 2(Nrf2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) as discussed below

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The development of technologies to assist in restoration of erythrocyte energy metabolism must form an integral part of new therapeutic strategies in the treatment of a great variety of disorders accompanied by inadequate oxygen delivery

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