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Besides their neuronal/plasma membrane location, it has been observed that a significant fraction of TRP channels is also present in organelles membranes which may be translocated as required by cells exposed to injury/inflammation (Mickle et al., 2016)

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By directly downregulating SIRT1, miR-34a leads to increased synthesis of inflammatory cytokines, including IL-6, TNF-α, IL-1β, and IL 8, and oxidative stress proteins, including MCP-1, vascular cell adhesion protein 1 (VCAM1), and MDA, and decreased levels of the anti-inflammatory cytokine IL-10 [297, 303]