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Therefore, since the statutory language does not expressly or implicitly exempt units of Medicare Part B or Part D MFP sales from the calculation of the manufacturer's ASP, we clarified in the CY 2026 PFS proposed rule (90 FR 32545 through 32546) that units of selected drugs sold at MFP are included in the calculation of the manufacturer's ASP described in section 1847A(c) of the Act effective January 1, 2026
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In DM, ROS generation depends on various routes, such as the enhanced formation of advanced glycation end products (AGEs), heightened polyol pathway, and stimulation of protein kinase C (PKC) (Kassab & Piwowar, 2012
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