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Emerging IGF-1 variants include those with site-specific pegylation (adding polyethylene glycol chains to further extend half-life), receptor-selective mutations that favor IGF-1R over InsR, and tissue-targeting peptides fused to IGF-1 to concentrate activity in specific organs
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[DOI] [PubMed] [Google Scholar] 80.Fakjian N., Buckpitt A.R
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