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Glutathione in Brain Disorders and Aging - PMC
Moreover, the catabolism of tryptophan into kynurenine by indoleamine 2,3-dioxygenase (IDO) downregulates TCR ζ-chain expression and promotes the differentiation of regulatory T cells, contributing to immunosuppression (105)
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NADPH participates in this reaction, which, in turn, is oxidized to NADP+, creating a redox cycle, which prevents distortions of the oxidant–antioxidant balance [29,49]
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