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Spatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARSโCoVโ2 Variants - Zhang - 2024 - Angewandte Chemie International Edition
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Employing this strategy to the ฮฒ-catenin-binding stapled peptides, the Chen group showed that the resulting compound is able to not only strongly inhibit Wnt signaling in cancer cells and APC โ/โ organoids but stall and even reduce tumor size in APC Min/+ mice, which is a common model with aberrant Wnt signaling used to simulate human familial adenomatous polyposis 112 and colorectal tumors
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